Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

Multiple myeloma is largely incurable, despite development of therapies that target myeloma cell-intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells, localized in specialized niches, which resist therapy and repopulate the tumour. However, little is known about the...

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Vydáno v:Nat Commun
Hlavní autoři: Lawson, Michelle A., McDonald, Michelle M., Kovacic, Natasa, Hua Khoo, Weng, Terry, Rachael L., Down, Jenny, Kaplan, Warren, Paton-Hough, Julia, Fellows, Clair, Pettitt, Jessica A., Neil Dear, T., Van Valckenborgh, Els, Baldock, Paul A., Rogers, Michael J., Eaton, Colby L., Vanderkerken, Karin, Pettit, Allison R., Quinn, Julian M. W., Zannettino, Andrew C. W., Phan, Tri Giang, Croucher, Peter I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686867/
https://ncbi.nlm.nih.gov/pubmed/26632274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9983
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