PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis

PICH is a SNF2 family DNA translocase that binds to ultra-fine DNA bridges (UFBs) in mitosis. Numerous roles for PICH have been proposed from protein depletion experiments, but a consensus has failed to emerge. Here, we report that deletion of PICH in avian cells causes chromosome structural abnorma...

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Publicat a:Nat Commun
Autors principals: Nielsen, Christian F., Huttner, Diana, Bizard, Anna H., Hirano, Seiki, Li, Tian-Neng, Palmai-Pallag, Timea, Bjerregaard, Victoria A., Liu, Ying, Nigg, Erich A., Wang, Lily Hui-Ching, Hickson, Ian D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686863/
https://ncbi.nlm.nih.gov/pubmed/26643143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9962
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