Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs

Methylglyoxal (MG) is a highly reactive glucose metabolic intermediate and a major precursor of advanced glycation end products. MG level is elevated in hyperglycemic disorders such as diabetes mellitus. Substantial evidence has shown that MG is involved in the pathogenesis of diabetes and diabetic...

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Dettagli Bibliografici
Pubblicato in:J Diabetes Res
Autori principali: Bo, Jinshuang, Xie, Shiya, Guo, Yi, Zhang, Chunli, Guan, Yanming, Li, Chunmei, Lu, Jianxin, Meng, Qing H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686727/
https://ncbi.nlm.nih.gov/pubmed/26779540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/2029854
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