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The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance

Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipas...

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Bibliographic Details
Published in:Exp Mol Med
Main Authors: Yoon, Mee-Sup, Choi, Cheol Soo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686696/
https://ncbi.nlm.nih.gov/pubmed/27534530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2015.93
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