Factors determining the stability, size distribution, and cellular accumulation of small, monodisperse chitosan nanoparticles as candidate vectors for anticancer drug delivery: application to the passive encapsulation of [(14)C]-doxorubicin

Development of parameters for the fabrication of nanosized vectors is pivotal for its successful administration in therapeutic applications. In this study, homogeneously distributed chitosan nanoparticles (CNPs) with diameters as small as 62 nm and a polydispersity index (PDI) of 0.15 were synthesiz...

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Publicado en:Nanotechnol Sci Appl
Autores principales: Masarudin, Mas Jaffri, Cutts, Suzanne M, Evison, Benny J, Phillips, Don R, Pigram, Paul J
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2015
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686320/
https://ncbi.nlm.nih.gov/pubmed/26715842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/NSA.S91785
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