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The COPII adaptor protein TMED7 is required to initiate and mediate the anterograde trafficking of Toll-like receptor 4 to the plasma membrane
Toll-like receptor 4 (TLR4), the receptor for the bacterial product endotoxin, is subject to multiple points of regulation at the levels of signaling, biogenesis, and trafficking. Dysregulation of TLR4 signaling can cause serious inflammatory diseases, such as sepsis. We found that the p24 family pr...
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| Udgivet i: | Sci Signal |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4685749/ https://ncbi.nlm.nih.gov/pubmed/25074978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005275 |
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