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Structural determinants of reductive terpene cyclization in iridoid biosynthesis

The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (Catharanthus roseus) bound to a mechanis...

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Bibliografiset tiedot
Julkaisussa:Nat Chem Biol
Päätekijät: Kries, Hajo, Caputi, Lorenzo, Stevenson, Clare E. M., Kamileen, Mohammed O., Sherden, Nathaniel H., Geu-Flores, Fernando, Lawson, David M., O’Connor, Sarah E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685742/
https://ncbi.nlm.nih.gov/pubmed/26551396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1955
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