Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP.

Fluid shear stress induces a number of morphological and functional changes in vascular endothelium, including a rapid and significant down-regulation of endothelin 1 (ET-1) mRNA and peptide release in bovine aortic endothelial cells. We show here that both the cell alignment and ET-1 down-regulatio...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Malek, A M, Greene, A L, Izumo, S
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1993
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46854/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8392184/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.13.5999
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