An ancestral host defence peptide within human β-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule

Host defence peptides (HDPs) are critical components of innate immunity. Despite their diversity, they share common features including a structural signature, designated “γ-core motif”. We reasoned that for each HDPs evolved from an ancestral γ-core, the latter should be the evolutionary starting po...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nigro, Ersilia, Colavita, Irene, Sarnataro, Daniela, Scudiero, Olga, Zambrano, Gerardo, Granata, Vincenzo, Daniele, Aurora, Carotenuto, Alfonso, Galdiero, Stefania, Folliero, Veronica, Galdiero, Massimiliano, Urbanowicz, Richard A., Ball, Jonathan K., Salvatore, Francesco, Pessi, Antonello
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685272/
https://ncbi.nlm.nih.gov/pubmed/26688341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18450
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