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Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance

Inflammasomes are multiprotein complexes that include members of the NOD-like receptor family and caspase-1. Caspase-1 is required for the fusion of the Legionella vacuole with lysosomes. Caspase-11, independently of the inflammasome, also promotes phagolysosomal fusion. However, it is unclear how t...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Caution, Kyle, Gavrilin, Mikhail A., Tazi, Mia, Kanneganti, Apurva, Layman, Daniel, Hoque, Sheshadri, Krause, Kathrin, Amer, Amal O.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685268/
https://ncbi.nlm.nih.gov/pubmed/26686473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18479
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