A Structure-activity Relationship of Non-peptide Macrocyclic Histone Deacetylase Inhibitors and Their Anti-proliferative and Anti-inflammatory Activities

Inhibition of the enzymatic activity of histone deacetylase (HDAC) is a promising therapeutic strategy for cancer treatment and several distinct small molecule histone deacetylase inhibitors (HDACi) have been reported. We have previously identified a new class of non-peptide macrocyclic HDACi derive...

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Gepubliceerd in:Bioorg Med Chem
Hoofdauteurs: Tapadar, Subhasish, Fathi, Shaghayegh, Raji, Idris, Omesiete, Wilson, Kornacki, James R., Mwakwari, Sandra C., Miyata, Masanori, Mitsutake, Kazunori, Li, Jian-Dong, Mrksich, Milan, Oyelere, Adegboyega K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685012/
https://ncbi.nlm.nih.gov/pubmed/26585275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.10.045
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