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Additive antinociceptive effects of mixtures of the kappa opioid receptor agonist spiradoline and the cannabinoid receptor agonist CP55940 in rats
OBJECTIVE: Pain is a significant clinical problem, and there is a need for pharmacotherapies that are more effective with fewer adverse effects. Cannabinoid receptor agonists enhance the antinociceptive effects of mu opioid receptor agonists; it is unclear whether they impact the effects of agonists...
Enregistré dans:
| Publié dans: | Behav Pharmacol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684971/ https://ncbi.nlm.nih.gov/pubmed/26292184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FBP.0000000000000184 |
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