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Activation of the aryl hydrocarbon receptor by 10-Cl-BBQ prevents insulitis and effector T cell development independently of Foxp3(+) regulatory T cells in NOD mice
AhR activation by high affinity ligands mediates immunosuppression in association with increased regulatory T cells, making this transcription factor an attractive therapeutic target for autoimmune diseases. We recently discovered 10-chloro-7H-benzimidazo[2,1-a]benzo[de]iso-quinolin-7-one (10-Cl-BBQ...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684970/ https://ncbi.nlm.nih.gov/pubmed/26573835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501789 |
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