Anticancer therapeutic potential of Mn porphyrin/ascorbate system

Ascorbate (Asc) as a single agent suppressed growth of several tumor cell lines in a mouse model. It has been tested in a Phase I Clinical Trial on pancreatic cancer patients where it exhibited no toxicity to normal tissue yet was of only marginal efficacy. The mechanism of its anticancer effect was...

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Publicat a:Free Radic Biol Med
Autors principals: Tovmasyan, Artak, Sampaio, Romulo S., Boss, Mary-Keara, Bueno-Janice, Jacqueline C., Bader, Bader H., Thomas, Milini, Reboucas, Julio S., Orr, Michael, Chandler, Joshua D., Go, Young-Mi, Jones, Dean P., Venkatraman, Talaignair N., Haberle, Sinisa, Kyui, Natalia, Lascola, Christopher, Dewhirst, Mark W., Spasojevic, Ivan, Benov, Ludmil, Batinic-Haberle, Ines
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684782/
https://ncbi.nlm.nih.gov/pubmed/26496207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.10.416
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