A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions

Patient-derived xenograft (PDX) models better represent human cancer than traditional cell lines. However, the complex in vivo environment makes it challenging to employ PDX models to investigate tumor-stromal interactions, such as those that mediate prostate cancer (PCa) bone metastasis. Thus, we e...

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Publicado en:Biomaterials
Autores principales: Fong, Eliza L. S., Wan, Xinhai, Yang, Jun, Morgado, Micaela, Mikos, Antonios G., Harrington, Daniel A., Navone, Nora M., Farach-Carson, Mary C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684431/
https://ncbi.nlm.nih.gov/pubmed/26599623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.10.059
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