New Infestin-4 Mutants with Increased Selectivity against Factor XIIa

Factor XIIa (fXIIa) is a serine protease that triggers the coagulation contact pathway and plays a role in thrombosis. Because it interferes with coagulation testing, the need to inhibit fXIIa exists in many cases. Infestin-4 (Inf4) is a Kazal-type inhibitor of fXIIa. Its specificity for fXIIa can b...

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Publicado no:PLoS One
Main Authors: Kolyadko, Vladimir N., Lushchekina, Sofya V., Vuimo, Tatiana A., Surov, Stepan S., Ovsepyan, Ruzanna A., Korneeva, Vera A., Vorobiev, Ivan I., Orlova, Nadezhda A., Minakhin, Leonid, Kuznedelov, Konstantin, Severinov, Konstantin V., Ataullakhanov, Fazoil I., Panteleev, Mikhail A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684401/
https://ncbi.nlm.nih.gov/pubmed/26670620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144940
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