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New Infestin-4 Mutants with Increased Selectivity against Factor XIIa

Factor XIIa (fXIIa) is a serine protease that triggers the coagulation contact pathway and plays a role in thrombosis. Because it interferes with coagulation testing, the need to inhibit fXIIa exists in many cases. Infestin-4 (Inf4) is a Kazal-type inhibitor of fXIIa. Its specificity for fXIIa can b...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Kolyadko, Vladimir N., Lushchekina, Sofya V., Vuimo, Tatiana A., Surov, Stepan S., Ovsepyan, Ruzanna A., Korneeva, Vera A., Vorobiev, Ivan I., Orlova, Nadezhda A., Minakhin, Leonid, Kuznedelov, Konstantin, Severinov, Konstantin V., Ataullakhanov, Fazoil I., Panteleev, Mikhail A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684401/
https://ncbi.nlm.nih.gov/pubmed/26670620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144940
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