Interactions Outside the Proteinase-binding Loop Contribute Significantly to the Inhibition of Activated Coagulation Factor XII by Its Canonical Inhibitor from Corn

Activated factor XII (FXIIa) is selectively inhibited by corn Hageman factor inhibitor (CHFI) among other plasma proteases. CHFI is considered a canonical serine protease inhibitor that interacts with FXIIa through its protease-binding loop. Here we examined whether the protease-binding loop alone i...

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Detalhes bibliográficos
Main Authors: Korneeva, Vera A., Trubetskov, Mikhail M., Korshunova, Alena V., Lushchekina, Sofya V., Kolyadko, Vladimir N., Sergienko, Olga V., Lunin, Vladimir G., Panteleev, Mikhail A., Ataullakhanov, Fazoil I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022879/
https://ncbi.nlm.nih.gov/pubmed/24706752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.553735
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