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Prestin-Dependence of Outer Hair Cell Survival and Partial Rescue of Outer Hair Cell Loss in Prestin (V499G/Y501H) Knockin Mice
A knockin (KI) mouse expressing mutated prestin (V499G/Y501H) (499 prestin) was created to study cochlear amplification. Recordings from isolated outer hair cells (OHC) in this mutant showed vastly reduced electromotility and, as a consequence, reduced hearing sensitivity. Although 499 prestin OHCs...
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| Publicado en: | PLoS One |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684303/ https://ncbi.nlm.nih.gov/pubmed/26682723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145428 |
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