Transient β-hairpin formation in α-synuclein monomer revealed by coarse-grained molecular dynamics simulation

Parkinson’s disease, originating from the intrinsically disordered peptide α-synuclein, is a common neurodegenerative disorder that affects more than 5% of the population above age 85. It remains unclear how α-synuclein monomers undergo conformational changes leading to aggregation and formation of...

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Bibliographic Details
Published in:J Chem Phys
Main Authors: Yu, Hang, Han, Wei, Ma, Wen, Schulten, Klaus
Format: Artigo
Language:Inglês
Published: AIP Publishing LLC 2015
Subjects:
Special Topic: Coarse Graining of Macromolecules, Biopolymers, and Membranes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684271/
https://ncbi.nlm.nih.gov/pubmed/26723627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.4936910
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