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Transient β-hairpin formation in α-synuclein monomer revealed by coarse-grained molecular dynamics simulation
Parkinson’s disease, originating from the intrinsically disordered peptide α-synuclein, is a common neurodegenerative disorder that affects more than 5% of the population above age 85. It remains unclear how α-synuclein monomers undergo conformational changes leading to aggregation and formation of...
Enregistré dans:
| Publié dans: | J Chem Phys |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
AIP Publishing LLC
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684271/ https://ncbi.nlm.nih.gov/pubmed/26723627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.4936910 |
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