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Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase

[Image: see text] A single mutation within a flavoprotein is capable of switching the catalytic activity of a dehalogenase into a nitroreductase. This change in function correlates with a destabilization of the one-electron-reduced flavin semiquinone that is differentially expressed in the nitro-FMN...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Mukherjee, Arnab, Rokita, Steven E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2015
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684082/
https://ncbi.nlm.nih.gov/pubmed/26616824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b07540
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