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Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase
[Image: see text] A single mutation within a flavoprotein is capable of switching the catalytic activity of a dehalogenase into a nitroreductase. This change in function correlates with a destabilization of the one-electron-reduced flavin semiquinone that is differentially expressed in the nitro-FMN...
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| Publicado no: | J Am Chem Soc |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2015
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684082/ https://ncbi.nlm.nih.gov/pubmed/26616824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b07540 |
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