Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion

Hematopoietic stem cells (HSCs) have emerged as promising therapeutic cell sources for high-risk hematological malignancies and immune disorders. However, their clinical use is limited by the inability to expand these cells ex vivo. Therefore, there is an urgent need to identify specific targets and...

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Pubblicato in:Sci Rep
Autori principali: Xie, Xiang-Qun, Yang, Peng, Zhang, Yu, Zhang, Peng, Wang, Liping, Ding, Yahui, Yang, Ming, Tong, Qin, Cheng, Haizi, Ji, Qing, McGuire, Terence, Yuan, Weiping, Cheng, Tao, Gao, Yingdai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683533/
https://ncbi.nlm.nih.gov/pubmed/26681454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18115
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