Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion

Hematopoietic stem cells (HSCs) have emerged as promising therapeutic cell sources for high-risk hematological malignancies and immune disorders. However, their clinical use is limited by the inability to expand these cells ex vivo. Therefore, there is an urgent need to identify specific targets and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Xie, Xiang-Qun, Yang, Peng, Zhang, Yu, Zhang, Peng, Wang, Liping, Ding, Yahui, Yang, Ming, Tong, Qin, Cheng, Haizi, Ji, Qing, McGuire, Terence, Yuan, Weiping, Cheng, Tao, Gao, Yingdai
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683533/
https://ncbi.nlm.nih.gov/pubmed/26681454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18115
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