Cysteines 208 and 241 in Ero1α are required for maximal catalytic turnover

Endoplasmic reticulum (ER) oxidoreductin 1α (Ero1α) is a disulfide producer in the ER of mammalian cells. Besides four catalytic cysteines (Cys(94), Cys(99), Cys(394), Cys(397)), Ero1α harbors four regulatory cysteines (Cys(104), Cys(131), Cys(208), Cys(241)). These cysteines mediate the formation o...

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Detalles Bibliográficos
Publicado en:Redox Biol
Main Authors: Ramming, Thomas, Kanemura, Shingo, Okumura, Masaki, Inaba, Kenji, Appenzeller-Herzog, Christian
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683387/
https://ncbi.nlm.nih.gov/pubmed/26609561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.11.004
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