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Intrauterine endotoxin-induced impairs pulmonary vascular function and right ventricular performance in infant rats and improvement with early vitamin D therapy

High pulmonary vascular resistance (PVR), proximal pulmonary artery (PA) impedance, and right ventricular (RV) afterload due to remodeling contribute to the pathogenesis and severity of pulmonary hypertension (PH). Intra-amniotic exposure to endotoxin (ETX) causes sustained PH and high mortality in...

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Pubblicato in:Am J Physiol Lung Cell Mol Physiol
Autori principali: Mandell, Erica, Powers, Kyle N., Harral, Julie W., Seedorf, Gregory J., Hunter, Kendall S., Abman, Steven H., Dodson, R. Blair
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683312/
https://ncbi.nlm.nih.gov/pubmed/26475735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00302.2015
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