Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2

Herpes simplex virus 2 (HSV-2) 0ΔNLS is a live HSV-2 ICP0 (-) mutant vaccine strain that is profoundly attenuated in vivo due to its interferon-hypersensitivity. Recipients of the HSV-2 0ΔNLS vaccine are resistant to high-dose HSV-2 challenge as evidenced by profound reductions in challenge virus sp...

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Bibliographic Details
Published in:PLoS One
Main Authors: Halford, William P., Geltz, Joshua, Messer, Ronald J., Hasenkrug, Kim J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682860/
https://ncbi.nlm.nih.gov/pubmed/26670699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145228
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