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‘BRCAness and its implications for platinum action in gynecologic cancer

Gynecologic cancers are major therapeutic targets of platinum-containing regimens. They may be particularly susceptible to these agents if their origins are related to hereditary BRCA-mutations; this implicates defective DNA repair secondary to inherited alterations in BRCA function. The concept of...

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Detalhes bibliográficos
Publicado no:Anticancer Res
Main Authors: Muggia, Franco, Safra, Tamar
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682661/
https://ncbi.nlm.nih.gov/pubmed/24510983
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