Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts

Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a proinvasive phenotype, which promotes extracellular matrix remodelling and collective invasion of cancer cells. Here we unveil that exposu...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Albrengues, Jean, Bertero, Thomas, Grasset, Eloise, Bonan, Stephanie, Maiel, Majdi, Bourget, Isabelle, Philippe, Claude, Herraiz Serrano, Cecilia, Benamar, Samia, Croce, Olivier, Sanz-Moreno, Victoria, Meneguzzi, Guerrino, Feral, Chloe C., Cristofari, Gael, Gaggioli, Cedric
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682161/
https://ncbi.nlm.nih.gov/pubmed/26667266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10204
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