Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid

Prenatal exposure to valproic acid (VPA), an established antiepileptic drug, has been reported to impair postnatal cognitive function in children born to VPA-treated epileptic mothers. However, how these defects arise and how they can be overcome remain unknown. Using mice, we found that comparable...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Juliandi, Berry, Tanemura, Kentaro, Igarashi, Katsuhide, Tominaga, Takashi, Furukawa, Yusuke, Otsuka, Maky, Moriyama, Noriko, Ikegami, Daigo, Abematsu, Masahiko, Sanosaka, Tsukasa, Tsujimura, Keita, Narita, Minoru, Kanno, Jun, Nakashima, Kinichi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682151/
https://ncbi.nlm.nih.gov/pubmed/26677766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.10.012
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