Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis

TANK Binding Kinase 1 (TBK1) is a non-canonical IκB kinase that contributes to KRAS-driven lung cancer. Here we report that TBK1 plays essential roles in mammalian cell division. Specifically, levels of active phospho-TBK1 increase during mitosis and localize to centrosomes, mitotic spindles and mid...

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Vydáno v:Nat Commun
Hlavní autoři: Pillai, Smitha, Nguyen, Jonathan, Johnson, Joseph, Haura, Eric, Coppola, Domenico, Chellappan, Srikumar
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682058/
https://ncbi.nlm.nih.gov/pubmed/26656453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10072
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