Phase I Trial of Weekly MK-0752 in Children with Refractory Central Nervous System Malignancies: A Pediatric Brain Tumor Consortium Study

PURPOSE: Amplification and high-levels of NOTCH ligand expression have been identified in several types of pediatric brain tumors. A phase I trial of weekly MK-0752, an oral inhibitor of gamma-secretase, was conducted in children with recurrent central nervous system (CNS) malignancies to estimate t...

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Veröffentlicht in:Childs Nerv Syst
Hauptverfasser: Hoffman, Lindsey M., Fouladi, Maryam, Olson, James, Daryani, Vinay M., Stewart, Clinton F., Wetmore, Cynthia, Kocak, Mehmet, Onar-Thomas, Arzu, Wagner, Lars, Gururangan, Sridharan, Packer, Roger J., Blaney, Susan M., Gajjar, Amar, Kun, Larry E., Boyett, James M., Gilbertson, Richard J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681692/
https://ncbi.nlm.nih.gov/pubmed/25930724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00381-015-2725-3
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