SBI-0640756 attenuates the growth of clinically unresponsive melanomas by disrupting the eIF4F translation initiation complex

Disrupting the eukaryotic translation initiation factor 4F (eIF4F) complex offers an appealing strategy to potentiate the effectiveness of existing cancer therapies and overcome resistance to drugs such as BRAF inhibitors (BRAFi). Here we identified and characterized the small molecule SBI-0640756 (...

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Publicado no:Cancer Res
Main Authors: Feng, Yongmei, Pinkerton, Anthony B., Hulea, Laura, Zhang, Tongwu, Davies, Michael A., Grotegut, Stefan, Cheli, Yann, Yin, Hongwei, Lau, Eric L., Kim, Hyungsoo, De, Surya K., Barile, Elisa, Pellecchia, Maurizio, Bosenberg, Marcus, Li, Jiang-Liang, James, Brian, Hassig, Christian A., Brown, Kevin M., Topisirovic, Ivan, Ronai, Ze'ev A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681635/
https://ncbi.nlm.nih.gov/pubmed/26603897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0885
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