miR-124 and androgen receptor signaling inhibitors repress prostate cancer growth by downregulating androgen receptor splice variants, EZH2 and Src

miR-124 targets the androgen receptor transcript, acting as a tumor suppressor to broadly limit the growth of prostate cancer (CaP). In this study, we unraveled the mechanisms through which miR-124 acts in this setting. miR-124 inhibited proliferation of CaP cells in vitro and sensitizes them to inh...

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Vydáno v:Cancer Res
Hlavní autoři: Shi, Xu-Bao, Ma, Ai-Hong, Xue, Lingru, Li, Meimei, Nguyen, Hao G., Yang, Joy C., Tepper, Clifford G., Gandour-Edwards, Regina, Evans, Christopher P., Kung, Hsing-Jien, deVere White, Ralph W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681619/
https://ncbi.nlm.nih.gov/pubmed/26573802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0795
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