Cyclin D1 Loss Distinguishes Prostatic Small Cell Carcinoma from Most Prostatic Adenocarcinomas

PURPOSE: Small cell neuroendocrine differentiation in prostatic carcinoma is an increasingly common resistance mechanism to potent androgen deprivation therapy (ADT), but can be difficult to identify morphologically. We investigated whether cyclin D1 and p16 expression can inform on Rb functional st...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Tsai, Harrison, Morais, Carlos L., Alshalalfa, Mohammed, Tan, Hsueh-Li, Haddad, Zaid, Hicks, Jessica, Gupta, Nilesh, Epstein, Jonathan I., Netto, George J., Isaacs, William B., Luo, Jun, Mehra, Rohit, Vessella, Robert L., Karnes, R. Jeffrey, Schaeffer, Edward M., Davicioni, Elai, De Marzo, Angelo M., Lotan, Tamara L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681606/
https://ncbi.nlm.nih.gov/pubmed/26246306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0744
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