Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model

BACKGROUND: The limited efficacy of current treatments against pancreatic cancer has prompted the search of new alternatives such as virotherapy. Activation of the immune response against cancer cells is emerging as one of the main mechanisms of action of oncolytic viruses (OV). Direct oncolysis rel...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Nistal-Villan, Estanislao, Bunuales, Maria, Poutou, Joanna, Gonzalez-Aparicio, Manuela, Bravo-Perez, Carlos, Quetglas, Jose I., Carte, Beatriz, Gonzalez-Aseguinolaza, Gloria, Prieto, Jesus, Larrea, Esther, Hernandez-Alcoceba, Ruben
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681018/
https://ncbi.nlm.nih.gov/pubmed/26671477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0479-x
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