A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2

Human BST-2 inhibits HIV-1 replication by tethering nascent virions to the cell surface. HIV-1 codes Vpu that counteracts BST-2 by down-regulating this restriction factor from the cell surface. This important function makes Vpu a potential therapeutic target. Yet, no agents have been reported to blo...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Mi, Zeyun, Ding, Jiwei, Zhang, Quan, Zhao, Jianyuan, Ma, Ling, Yu, Haisheng, Liu, Zhenlong, Shan, Guangzhi, Li, Xiaoyu, Zhou, Jinming, Wei, Tao, Zhang, Liguo, Guo, Fei, Liang, Chen, Cen, Shan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4680884/
https://ncbi.nlm.nih.gov/pubmed/26669976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18499
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