Silencing of SIAH1 in SH-SY5Y affects α-synuclein degradation pathway

Seven in absentia homolog (SIAH) is a ubiquitin ligase that monoubiquitinates α-synuclein. Lewy bodies are characteristically rich in monoubiquitinated α-synuclein. We aimed to determine the effect of siRNA-SIAH1 on α-synuclein autophagy and UPS degradation in SH-SY5Y. SIAH1 expression was measured...

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Bibliografske podrobnosti
izdano v:Int J Clin Exp Pathol
Main Authors: Xu, Jing, Zhang, Xin-Zhi, Zhang, Yong-Jin, Li, Xiu-Ming, Cai, Zeng-Lin, Li, Xiao-Min
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2015
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4680425/
https://ncbi.nlm.nih.gov/pubmed/26722480
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