C-terminal region of GADD34 regulates eIF2α dephosphorylation and cell proliferation in CHO-K1 cells

GADD34 is a member of a growth arrest and DNA damage (GADD)-inducible gene family. Here, we established a novel Chinese hamster ovary (CHO)-K1-derived cell line, CHO-K1-G34M, which carries a nonsense mutation (termed the Q525X mutation) in the GADD34 gene. The Q525X mutant protein lacks the C-termin...

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Publié dans:Cell Stress Chaperones
Auteurs principaux: Otsuka, Ryo, Harada, Nagakatsu, Aoki, Shouhei, Shirai, Kanna, Nishitsuji, Kazuchika, Nozaki, Ayane, Hatakeyama, Adzumi, Shono, Masayuki, Mizusawa, Noriko, Yoshimoto, Katsuhiko, Nakaya, Yutaka, Kitahata, Hiroshi, Sakaue, Hiroshi
Format: Artigo
Langue:Inglês
Publié: Springer Netherlands 2015
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Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679745/
https://ncbi.nlm.nih.gov/pubmed/26318739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-015-0633-9
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