The protease cathepsin L regulates Th17 cell differentiation

Previously we reported that IL-17(+) T cells, primarily IL-17(+) γδ cells, are increased in mice lacking the protease inhibitor serpinB1 (serpinb1(−/−) mice). Here we show that serpinB1-deficient CD4 cells exhibit a cell-autonomous and selective deficiency in suppressing T helper 17 (Th17) cell diff...

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Bibliografiska uppgifter
I publikationen:J Autoimmun
Huvudupphovsmän: Hou, Lifei, Cooley, Jessica, Swanson, Richard, Ong, Poh Chee, Pike, Robert N., Bogyo, Matthew, Olson, Steven T., Remold-O’Donnell, Eileen
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679515/
https://ncbi.nlm.nih.gov/pubmed/26343333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2015.08.006
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