Mucosal delivery switches the response to an adjuvanted tuberculosis vaccine from systemic T(H)1 to tissue-resident T(H)17 responses without impacting the protective efficacy(§)

Pulmonary tuberculosis (TB) remains one of the leading causes of infectious disease death despite widespread usage of the BCG vaccine. A number of new TB vaccines have moved into clinical evaluation to replace or boost the BCG vaccine including ID93+GLA-SE, an adjuvanted subunit vaccine. The vast ma...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Orr, Mark T., Beebe, Elyse A., Hudson, Thomas, Argilla, David, Huang, Po-Wei D., Reese, Valerie A., Fox, Christopher B., Reed, Steven G., Coler, Rhea N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679420/
https://ncbi.nlm.nih.gov/pubmed/26541135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2015.10.115
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