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Correcting gene expression data when neither the unwanted variation nor the factor of interest are observed

When dealing with large scale gene expression studies, observations are commonly contaminated by sources of unwanted variation such as platforms or batches. Not taking this unwanted variation into account when analyzing the data can lead to spurious associations and to missing important signals. Whe...

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Dettagli Bibliografici
Pubblicato in:Biostatistics
Autori principali: Jacob, Laurent, Gagnon-Bartsch, Johann A., Speed, Terence P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679071/
https://ncbi.nlm.nih.gov/pubmed/26286812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxv026
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