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Correcting gene expression data when neither the unwanted variation nor the factor of interest are observed

When dealing with large scale gene expression studies, observations are commonly contaminated by sources of unwanted variation such as platforms or batches. Not taking this unwanted variation into account when analyzing the data can lead to spurious associations and to missing important signals. Whe...

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Publicat a:Biostatistics
Autors principals: Jacob, Laurent, Gagnon-Bartsch, Johann A., Speed, Terence P.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679071/
https://ncbi.nlm.nih.gov/pubmed/26286812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxv026
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