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Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein response

Cells of the innate immune system recognize bacterial pathogens by detecting common microbial patterns as well as pathogen-specific activities. One system that responds to these stimuli is the IRE1 branch of the unfolded protein response (UPR), a sensor of endoplasmic reticulum (ER) stress. Activati...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hempstead, Andrew D., Isberg, Ralph R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679008/
https://ncbi.nlm.nih.gov/pubmed/26598709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508716112
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