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Autophagy protects against de novo formation of the [PSI(+)] prion in yeast

Prions are self-propagating, infectious proteins that underlie several neurodegenerative diseases. The molecular basis underlying their sporadic formation is poorly understood. We show that autophagy protects against de novo formation of [PSI(+)], which is the prion form of the yeast Sup35 translati...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Speldewinde, Shaun H., Doronina, Victoria A., Grant, Chris M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678013/
https://ncbi.nlm.nih.gov/pubmed/26490118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-08-0548
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