Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths

Helminth infection is frequently associated with the expansion of regulatory T cells (Tregs) and suppression of immune responses to bystander antigens. We show that infection of mice with the chronic gastrointestinal helminth Heligmosomoides polygyrus drives rapid polyclonal expansion of Foxp3(+)Hel...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Smith, K A, Filbey, K J, Reynolds, L A, Hewitson, J P, Harcus, Y, Boon, L, Sparwasser, T, Hämmerling, G, Maizels, R M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677460/
https://ncbi.nlm.nih.gov/pubmed/26286232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2015.73
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