Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven inhibition of host immunity during chronic infection. We addressed whether parasites can directly induce T reg cells. Foxp3 expression was stimulated in naive Foxp3(−) T cells in mice infected with the intestinal hel...

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Detalhes bibliográficos
Main Authors: Grainger, John R., Smith, Katie A., Hewitson, James P., McSorley, Henry J., Harcus, Yvonne, Filbey, Kara J., Finney, Constance A.M., Greenwood, Edward J.D., Knox, David P., Wilson, Mark S., Belkaid, Yasmine, Rudensky, Alexander Y., Maizels, Rick M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964568/
https://ncbi.nlm.nih.gov/pubmed/20876311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20101074
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