Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation

BACKGROUND: Metabolic complications such as obesity, hyperglycemia, and type 2 diabetes are associated with poor outcomes in patients with glioblastoma. To control peritumoral edema, use of chronic high-dose steroids in glioblastoma patients is common, which can result in de novo diabetic symptoms....

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Gong, Yuanying, Ma, Yufang, Sinyuk, Maksim, Loganathan, Sudan, Thompson, Reid C., Sarkaria, Jann N., Chen, Wenbiao, Lathia, Justin D., Mobley, Bret C., Clark, Stephen W., Wang, Jialiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677408/
https://ncbi.nlm.nih.gov/pubmed/26136493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov096
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