Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1)

BACKGROUND: Hematologic toxicity represents a major side effect of cytotoxic chemotherapy frequently preventing adequately dosed chemotherapy application and impeding therapeutic success. Transgenic (over)expression of chemotherapy resistance (CTX-R) genes in hematopoietic stem- and progenitor cells...

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Publicado en:J Exp Clin Cancer Res
Autores principales: Brennig, Sebastian, Lachmann, Nico, Buchegger, Theresa, Hetzel, Miriam, Schambach, Axel, Moritz, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676838/
https://ncbi.nlm.nih.gov/pubmed/26651614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0260-4
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