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The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects
RNA interference (RNAi) is a powerful tool for post-transcriptional gene silencing. However, the siRNA guide strand may bind unintended off-target transcripts via partial sequence complementarity by a mechanism closely mirroring micro RNA (miRNA) silencing. To better understand these off-target effe...
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| Publicado no: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4676691/ https://ncbi.nlm.nih.gov/pubmed/26657993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004656 |
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