Identification of agents that reduce renal hypoxia-reoxygenation injury using cell-based screening: purine nucleosides are alternative energy sources in LLC-PK1 cells during hypoxia

Acute tubular necrosis is a clinical problem that lacks specific therapy and is characterized by high mortality rate. The ischemic renal injury affects the proximal tubule cells causing dysfunction and cell death after severe hypoperfusion. We utilized a cell-based screening approach in a hypoxia-re...

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Bibliographische Detailangaben
Veröffentlicht in:Arch Biochem Biophys
Hauptverfasser: Szoleczky, Petra, Módis, Katalin, Nagy, Nóra, Tóth, Zoltán Dóri, DeWitt, Douglas, Szabó, Csaba, Gerő, Domokos
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676579/
https://ncbi.nlm.nih.gov/pubmed/22100704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.11.005
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