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Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression
Inflammasomes are cytoplasmic, multiprotein complexes that trigger caspase-1 activation and IL-1β maturation in response to diverse stimuli. Although inflammasomes play important roles in host defense against microbial infection, overactive inflammasomes are deleterious and lead to various autoinfla...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4675967/ https://ncbi.nlm.nih.gov/pubmed/26659006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17935 |
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